Some emergency services and Intensive Care Units use lactate serum rate to qualitative resuscitation between patients with severe sepsis, but there is a general concept to use Central Venous Pressure and Central venous Oxygen Saturation as physiological purposes of resuscitation. Little is known about biomarkers which are used to classification of patients in order to diagnosis severity of sepsis among clients of emergency units. It seems that Lactate clearance can be used in this regard. This study aimed to determine the relationship between Lactate clearance, mortality and organ dysfunction with severe sepsis.

In this study, 90 patients with severe sepsis were visited and examined. Upon admission a complete description of demographic variables, history of medical visits and tests were gathered by the researchers, and the tests were repeated 6 hours later.

In this study, significant relationship was found between the number of deficient organs and the mortality rate and an increase in the APACHE2 score. The situation can be ascribed to the severity of diseases as well as insufficient early treatments or delayed resuscitation activities.

The authors concluded that severe sepsis is a marker which is related to tissue hypoxia, that an increase in lactate clearance is related to a drastic reduction in biomarkers, mortality, and incidence of organ dysfunction. Overall, patients with lower lactate clearance are considered a high risk group for mortality and organ dysfunction.

This article was written by Ehsan Bolvardi, Jafar Malmir, Hamidreza Reihani, Amir Masoud Hashemian, Mehran Bahramian, Peyman Khademhosseini and Koorosh Ahmadi, and it was published by Mater Sociomed. 2016 Feb; 28(1): 57-60

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