Lactate clearance and mortality in pediatric sepsis

This article was written by Dedi K. Saputra, Ari L. Runtunuwu, Suryadi N. N. Tatura, Jeanette I. Ch. Manoppo and Julius H. Lolombulan, and published in 2016 by Paediatrica Indonesiana (Paediatr Indones, Vol. 56, No. 4, July 2016)

Sepsis is a life-threatening condition, with a high mortality rate, which is often found in the paediatric intensive care unit. Serum lactate concentration is useful to evaluate the progression of sepsis in children.

With this study, the authors aim to evaluate the relationship between lactate clearance and patient mortality, as well as to assess the usefulness of lactate clearance as an early prognostic marker in paediatric sepsis.

After performing a prospective cohort study for 5 months in an Indonesian hospital, Saputra et al. concluded that higher lactate clearance significantly associates with lower mortality rate in children with sepsis.

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