Lactate Level as a Predictor of Mortality in Patients with Septic Shock

Please find below the abstract of the article written in Spanish by Gualterio Jasso-Contreras, Felipe González-Velázquez, Leidiana Bello-Aguilar, Andrea García-Carrillo, Mario Ramón Muñoz-Rodríguez and Luis Pereda-Torales. The original title of this article is “Niveles de lactato como predictor de mortalidad en  pacientes con choque séptico”, and the translation in English would be “Lactate Level as a Predictor of Mortality in Patients with Septic Shock”. This article was published by Revista Médica del Instituto Mexicano del Seguro Social (Rev Med Inst Mex Seguro Soc. 2015;53(3):316-21)

Background: The objective was to determine the association between serum lactate levels and mortality in patients with septic shock in the Emergency Room of the Instituto Mexicano del Seguro Social’s Centro Médico Nacional Adolfo Ruiz Cortines.

Methods: We included the patients admitted to the Emergency Room with diagnosis of septic shock who had measure of serum lactate at admission during the period 01-12/2013; it was a case-control study. The cut-off value of serum lactate associated with mortality was performed using the ROC (receiver operating characteristic) curves.

Results: Sixty-seven patients were studied, out of which 56 survived (cases) and 11 died (controls). There was no association with gender, age and comorbidities. The cut-off value for mortality of serum lactate was 4.9 mmol/L. Ten patients out of 40 with lactate levels > 4.9 mmol/L, and only one out of 27 with lactate < 4.9 mmol/L died (p = 0.04); odds ratio was of 8.7. The mortality in patients with septic shock and lactate > 4.9mmol/ is high and had a sensitivity of 90.9 % and specifi city of 46.4 %.

Conclusions: The levels of serum lactate greater than four are associated to an increased risk of mortality in patients with septic shock.

Please click here to download the original article, written in Spanish:
Etiology and Therapeutic Approach to Elevated Lactate Levels