This study, carried out by Pan et al. and published in January 2019 by Medicine, involves a meta-analysis of different articles published between 1976 and February 2018, which aims to evaluate the effect of early therapy guided by lactate clearance as a potentially more effective resuscitation objective.

Recent studies suggest that lactate normalisation during resuscitation is a more powerful indicator of resuscitative adequacy than therapy guided by continuous central venous oxygen saturation (ScvO2).

The authors studied a total of 108 articles that fulfilled the inclusion requirements, of which 7 randomized controlled studies were finally reviewed.

Compared with therapy guided by continuous central venous oxygen saturation (ScvO2), early therapy aimed at lactate clearance was associated with a decreasedn in-hospital mortality, a shorter stay in the ICU, a shorter mechanical ventilation time and lower APACHE-II scores.

After analysing the results of this study, Pan et al. concluded that as a specific indicator of the  resuscitation result, lactate clearance is superior to ScvO2 during a standard resuscitation paradigm.

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